Validation of Protein Markers for Lung Cancer Using CARET Sera and Proteomics Techniques

Abbreviated Name
Lung CARET
Lead Investigator
Hanash, SamirThe University of Texas MD Anderson Cancer Center
Coordinating Investigator
Feng, Ziding Fred Hutchinson Cancer Center
Involved Investigators

Abstact

see objectives

Aims

Aim 1: To validate the finding from pilot studies with CARET sera of autoantibodies to annexins I and II and PGP9.5 as potential biomarkers for lung cancers before the clinical diagnosis. Aim 2: To identify additional antigens and antibodies in sera from CARET participants, evaluating sensitivity and specificity by time before diagnosis, treatment arm, gender, and histologic type. Aim 3: To compare the findings for individual biomarker candidates and combinations of biomarker candidates in participants who were current smokers versus former smokers.

Analytic Method

Natural Array technique

Publications

Biomarkers

Data Collections

Start Date
Sep 5 2006
Estimated Finish Date
Sep 5 2007
Finish Date
Aug 7 2007
Protocol ID
138
Protocol Type
Validation
Field of Research
Proteomics
Collaborative Group
Lung and Upper Aerodigestive Cancers Research Group
Cancer Types
  • Malignant neoplasm of bronchus and lung
Phased Status
2

Associated Forms