Specimen Reference Sets

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Read the EDRN Pre/Validation Reference Set Specimen Sharing Guidelines.

Organ Protocol ID Reference set title Cases Controls Total participants Participants groups Specimen type Number of specimens Volume range (mL) Specimens at NCI-F? Sequential samples? Follow-up data? Pathology Image files avail? Incidental cancer?
Bladder

108

MSA/Bladder Ref set (Discovery)

234 191 425 Serum 2,554 0.03–0.05

⁠DNA from blood

Urine DNA
Breast

331

Benign Breast Disease

30 62 92 BBD that progressed to cancer BBD controls Tissue slides 9,256 "each" No, at Kansas N/A ⁠✓

Breast

121

Breast Reference Set and Imaging

262 570 832 Pre-diagnosis specimens, DCIS cases, Invasive cancer cases, LCIS cases, Benign→later cancer cases, Normal→later cancer cases, Benign Disease Atypia controls, Benign Disease non-Atypia controls, Normal controls Serum 16,444 0.01–0.8

Plasma 16,169 0.01–0.9

Ovarian & Breast

118

Cancers in women-BRSCW

441 95 536 Cases (pooled), controls (pooled) Serum 105 sets 0.3

Colon

251

Colon cancer

50 100 150 Serum 2,100 0.3

Plasma 1500 0.3

Urine 150 5

HEDS

316

Hepatocellular carcinoma Early Detection Strategy study (HEDS)

114 1609 1723 N/A Serum 45,605 0.100-5.0

N/A Plasma 46,727 0.100-5.0

N/A DNA 1,264 0.1-.05
Liver

111

DCP/Liver Ref set Rapid set

50 50 100 Serum 1,329 0.01–0.5

Plasma 731 0.2–0.5

Liver

111

DCP/Liver Ref set Validation set

427 432 871 Serum 10,815 0.01–1.0

Plasma 5,090 0.2–0.5

Lung

354

Lung Team Project №2

⁠193 92 286 ⁠Serum ⁠4,257 ⁠0.05–0.5 ⁠✓ ⁠✓ A few data elements ⁠at 1 time point
⁠⁠

⁠⁠

⁠⁠

Plasma 4,286 0.05–2.0
Lung

115

Lung Ref Set A Phase 2 Validation (retrospective)
(Discovery)

268 309 577 Serum 3,695 0.025–0.5

Plasma 5,267 0.15–0.3
Lung

115

Lung Ref Set B (retrospective)

86 147 233 Plasma 3,846 0.025–0.375
Lung

115

Lung Ref Set C (prospective)

159 195 354 Serum 6,430 0.015–0.2

Plasma 6,787 0.01–0.175

Pancreas

185

Pancreatic cancer

100 155 255 Serum 4,847 0.1–0.8

Plasma 3,006 0.2–0.8

Prostate

274

Prostate cancer (from PCA3)

341 559 900 Serum 16,778 0.075–0.5

Buffy coat 864 0.05–0.5

Whole urine 771 1.2–5.0

EDTA plasma 13,137 0.1

Sediment/RNALater 738 0.035–1.5

Sediment/PBS 486 0.01–0.4

Supernatant 1,493 2.5–50

PAXGene 1,716 "tubes"

Pancreas

342

Panc Cyst

48 270 318 Serum 16,958 0.1–0.3

EDTA plasma 8,605 0.1–0.3

EUS cystic fluid 5,538 0.05–0.1

Surgical cystic fluid 4,599 0.1–0.6