- 14-3-3 protein T-cell
- 14-3-3 protein tau
- 14-3-3 protein theta
- 14-3-3 theta
- Protein HS1
- protein tau
- tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
- YWHAQ, also known as 14-3-3 theta, belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse and rat orthologs. The 14-3-3 proteins have a wide range of ligands, are involved in a variety of biological pathways, and are known to be overexpressed in some human lung cancers, suggesting that they may play a role in tumorigenesis. 14-3-3 theta is an adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. It binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. 14-3-3 theta antigens have been found to be targets of autoantibodies in subjects newly diagnosed with lung cancer.
- QA State
- HGNC Name
- QA State for Lung
- Under Review
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- Autoantibody profiling for cancer detection.
- Identification of 14-3-3 theta as an antigen that induces a humoral response in lung cancer.
- Isoform-specific expression of 14-3-3 proteins in human lung cancer tissues.
- Lung cancer signatures in plasma based on proteome profiling of mouse tumor models.
- Occurrence of autoantibodies to annexin I, 14-3-3 theta and LAMR1 in prediagnostic lung cancer sera.
- Reduction of 14-3-3 proteins correlates with increased sensitivity to killing of human lung cancer cells by ionizing radiation.
- The state of molecular biomarkers for the early detection of lung cancer.