Biomarkers to Distinguish Aggressive Cancers from Non-aggressive or Non- progressing cancers

Abbreviated Name
William Rom Supplement 2012
Lead Investigator
Rom, WilliamNew York University School of Medicine
Coordinating Investigator
No coordinating investigator
Involved Investigators

Abstract

No abstract availalbe.

Aims

Specific Aim 1. Develop a novel biomarker panel based on our auto-antibody publication and our development of an Immunoruler using auto-antibodies to glycosylated proteins using synthetic glycans printed on glass microarray technology. Specific Aim 2. Test the autoantibody panels on CT-scan screen-detected lung cancers including both indolent and aggressive cancers, and validate with thoracic surgery lung cancer cases stratified by no recurrence within three years “indolent” and recurrent within three years “aggressive.” Each lung cancer case will be matched to a control with normal CT scans by smoking, gender, and age.

Analytic Method

development of an Immunoruler using auto-antibodies to glycosylated proteins using synthetic glycans printed on glass microarray technology. Each sample will be assessed in triplicates, and the average value at 490 nm will be used for data analysis. During the 02 year we will be focusing our efforts at completing the assays and data analysis.

Publications

  • No publications available at this time for this protocol.

Biomarkers

Data Collections

  • No data collections available at this time for this protocol.
 Team Project
Start Date
Jul 1 2012
Estimated Finish Date
Jun 30 2013
Finish Date
Dec 31 2015
Protocol ID
361
Protocol Type
Collaboration
Fields of Research
  • Glycomics
Collaborative Group
Lung and Upper Aerodigestive Cancers Research Group
Cancer Types
  • Malignant neoplasm of bronchus and lung

Associated Forms