Rom, William

Open Protocols

Protocol Name Investigatory Role Biomarkers Data Collections
NYU Lung Cancer Biomarker Center Leading 2 0
Validation of Molecular Biomarkers for the Early Detection of Lung Cancer in the setting of Indeterminate Pulmonary Nodules (Lung Team Project #2) Involved 15 1

Closed Protocols

Protocol Name Investigatory Role Biomarkers Data Collections
Biomarkers to Distinguish Aggressive Cancers from Non-aggressive or Non- progressing cancers Leading 17 0
EDRN Resource Network Exchange Involved 0 0
Soluble Mesothelin Related Peptide (SMRP) and Osteopontin (OPN) as Early Detection Markers for Malignant Mesothelioma (MM) Involved 4 0
Standard Specimen Reference Set: Lung Involved 0 0


Publication NamePubMed IDJournal
4-aminobiphenyl is a major etiological agent of human bladder cancer: evidence from its DNA binding spectrum in human p53 gene. 12376482 Carcinogenesis
Chromium(VI) exposure enhances polycyclic aromatic hydrocarbon-DNA binding at the p53 gene in human lung cells. 12727806 Carcinogenesis
Cigarette smoke induces methylation of the tumor suppressor gene NISCH. 23503203 Epigenetics
Clinical correlation of asbestos bodies in BAL fluid. 15364780 Chest
CT scan screening for lung cancer: risk factors for nodules and malignancy in a high-risk urban cohort. 22768300 PLoS One
Detection of lung cancer using weighted digital analysis of breath biomarkers. 18420034 Clin Chim Acta
Distinctive serum protein profiles involving abundant proteins in lung cancer patients based upon antibody microarray analysis. 16117833 BMC Cancer
Effect of CpG methylation at different sequence context on acrolein- and BPDE-DNA binding and mutagenesis. 23042304 Carcinogenesis
Functional genomics in lung cancer and biomarker detection. 12878582 Am J Respir Cell Mol Biol
Gender and lung cancer. 15217534 Clin Lung Cancer
Gene expression profiles in peripheral blood mononuclear cells can distinguish patients with non-small cell lung cancer from patients with nonmalignant lung disease. 19951989 Cancer Res
Glucocorticoids inhibit lung cancer cell growth through both the extracellular signal-related kinase pathway and cell cycle regulators. 12204894 Am J Respir Cell Mol Biol
Identification of an autoantibody panel to separate lung cancer from smokers and nonsmokers. 20504322 BMC Cancer
Impact of a computer-aided detection (CAD) system integrated into a picture archiving and communication system (PACS) on reader sensitivity and efficiency for the detection of lung nodules in thoracic CT exams. 22710985 J Digit Imaging
In vitro mechanisms of lovastatin on lung cancer cell lines as a potential chemopreventive agent. 18034278 Lung
Longitudinal multistage model for lung cancer incidence, mortality, and CT detected indolent and aggressive cancers. 22705252 Math Biosci
Molecular analysis of plasma DNA for the early detection of lung cancer by quantitative methylation-specific PCR. 20592015 Clin Cancer Res
Molecular and genetic aspects of lung cancer. 10764334 Am J Respir Crit Care Med
Mutational spectrum and genotoxicity of the major lipid peroxidation product, trans-4-hydroxy-2-nonenal, induced DNA adducts in nucleotide excision repair-proficient and -deficient human cells. 12820894 Biochemistry
N-hydroxy-4-aminobiphenyl-DNA binding in human p53 gene: sequence preference and the effect of C5 cytosine methylation. 12009904 Biochemistry
Optical detection of buccal epithelial nanoarchitectural alterations in patients harboring lung cancer: implications for screening. 20924114 Cancer Res
Performance of mitochondrial DNA mutations detecting early stage cancer. 18834532 BMC Cancer
Prediction of lung cancer using volatile biomarkers in breath. 17522431 Cancer Biomark
Preferential carcinogen-DNA adduct formation at codons 12 and 14 in the human K-ras gene and their possible mechanisms. 12924950 Biochemistry
Preferential DNA damage and poor repair determine ras gene mutational hotspot in human cancer. 12381705 J Natl Cancer Inst
Resection of non-small cell lung cancers reverses tumor-induced gene expression changes in the peripheral immune system. 21807633 Clin Cancer Res
S-adenosylmethionine as a biomarker for the early detection of lung cancer. 17934114 Chest
Selective p38 activation in human non-small cell lung cancer. 11970907 Am J Respir Cell Mol Biol
Sequence specificity of Cr(III)-DNA adduct formation in the p53 gene: NGG sequences are preferential adduct-forming sites. 16251206 Carcinogenesis
Sputum-based molecular biomarkers for the early detection of lung cancer: limitations and promise. 24212941 Cancers (Basel)
Standard operating procedures for serum and plasma collection: early detection research network consensus statement standard operating procedure integration working group. 19072545 J Proteome Res
Unlocking biomarker discovery: large scale application of aptamer proteomic technology for early detection of lung cancer. 21170350 PLoS One
Variant Ciz1 is a circulating biomarker for early-stage lung cancer. 23074256 Proc Natl Acad Sci U S A


Genetic profile of preneoplastic lesions
Genetic profile of preneoplastic lesions and alteration of the profile with inhaled corticosteroids.
Lung Cancer
Early detection biomarkers

To update protocols, publications, biomarkers, or science data, please contact the Data Management and Coordinating Center.

Photograph of Rom, William
New York University School of Medicine
M.D., M.P.H
(212) 263-8442
Person ID
EDRN Title
EDRN Associate Member
To update contact information, please visit the Data Management and Coordinating Center .