TNFSF8
- Aliases
-
- CD153
- CD153 antigen
- CD30 antigen ligand
- CD30 ligand
- CD30-L
- CD30L
- CD30LG
- TNFSF8
- tumor necrosis factor (ligand) superfamily, member 8
- tumor necrosis factor ligand superfamily member 8
- Description
- TNFSF8, also known as CD30 ligand, is a cytokine belonging to the tumor necrosis factor (TNF) ligand family. TNFSF8 binds to TNFRSF8/CD30, a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. TNFSF8 has been shown to induce proliferation of T-cells. It also enhances cell proliferation of some lymphoma cell lines, and induces cell death and reduces cell proliferation of other lymphoma cell lines. There are two different isoforms encoded by two transcript variants.
Attributes
- QA State
- Curated
- Type
- Protein
- HGNC Name
- TNFSF8
- Certifications
-
- None
- QA State for Lung
- Curated
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
- Association of a novel functional promoter variant (rs2075533 C>T) in the apoptosis gene TNFSF8 with risk of lung cancer--a finding from Texas lung cancer genome-wide association study.
- The state of molecular biomarkers for the early detection of lung cancer.
- Unlocking biomarker discovery: large scale application of aptamer proteomic technology for early detection of lung cancer.
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.