pleiotrophin
- Aliases
-
- HARP
- HB-GAM
- HBBM
- HBGF-8
- HBGF8
- HBNF
- HBNF-1
- HBNF1
- Heparin-binding brain mitogen
- Heparin-binding growth factor 8
- Heparin-binding growth-associated molecule
- Heparin-binding neurite outgrowth-promoting factor 1
- NEGF1
- OSF-1
- Osteoblast-specific factor 1
- PTN
- heparin affin regulatory protein
- heparin binding growth factor 8
- heparin-binding brain mitogen
- heparin-binding growth factor 8
- heparin-binding growth-associated molecule
- heparin-binding neurite outgrowth-promoting factor 1
- neurite growth-promoting factor 1
- osteoblast-specific factor 1
- pleiotrophin
- pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1)
- Description
- Pleiotrophin, or PTN, is a secreted growth factor found in osteoblasts and brain tissue. PTN induces neurite outgrowth and is mitogenic for fibroblasts, epithelial, and endothelial cells. It binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation.
Attributes
- QA State
- Curated
- Type
- Protein
- HGNC Name
- PTN
- Certifications
-
- None
- QA State for Lung
- Curated
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.