ANXA1
- Aliases
-
- ANX1
- ANXA1
- Annexin 1
- Annexin A1
- Annexin I
- Annexin-1
- Calpactin II
- Chromobindin-9
- LPC1
- Lipocortin I
- Phospholipase A2 inhibitory protein
- p35
- Description
- Annexin 1 belongs to a family of calcium-dependent phospholipid binding proteins which are preferentially located on the cytosolic face of the plasma membrane. Annexin I protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins and leukotrienes, annexin I may have potential anti-inflammatory activity. Annexin 1 also promotes membrane fusion and is involved in exocytosis. It seems to bind from two to four calcium ions with high affinity.
Attributes
- QA State
- Accepted
- Type
- Protein
- HGNC Name
- ANXA1
- Certifications
-
- None
- QA State for Breast
- Curated
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
- Certifications
-
- None
- QA State for Lung
- Under Review
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
- An immune response manifested by the common occurrence of annexins I and II autoantibodies and high circulating levels of IL-6 in lung cancer.
- Autoantibody profiling for cancer detection.
- Construction and analysis of the NCI-EDRN breast cancer reference set for circulating markers of disease.
- Development of a multiplexed tumor-associated autoantibody-based blood test for the detection of non-small cell lung cancer.
- Integral protein microarrays for the identification of lung cancer antigens in sera that induce a humoral immune response.
- Lung cancer signatures in plasma based on proteome profiling of mouse tumor models.
- Occurrence of autoantibodies to annexin I, 14-3-3 theta and LAMR1 in prediagnostic lung cancer sera.
- The state of molecular biomarkers for the early detection of lung cancer.