Bigbee, William L.

Open Protocols

Protocol Name Investigatory Role Biomarkers Data Collections
Collaborative study on SELDI biomarker discovery and serum protein profiling of lung cancers Involved 0 0
EDRN Informatics Pilot Project Leading 0 0

Closed Protocols

Protocol Name Investigatory Role Biomarkers Data Collections
Autoantibody Approach for Serum-Based Detection of Head and Neck Cancer Involved 8 0
EDRN Resource Network Exchange Involved 0 0
EDRN-WHI Pre-Clinical Colon Ca Specimens Involved 0 1
Proteomic Approach for Diagnostic Applications in Head and Neck Cancer Involved 0 0
Proteomic Profiling of Serum and Other Body Fluids for the Early Detection of Colon Cancers Involved 0 0
SELDI Phase I: Assay Validation-Prostate Involved 1 1
SELDI Validation Study Phase II Involved 1 1
Standard Specimen Reference Set: Lung Leading 0 0


Publication NamePubMed IDJournal
[Analysis of proteomic spectra in serum from patients with laryngeal carcinoma by SELDI-TOF-MS technology]. 20359086 Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
[Rabies vaccination with regards to its epidemiology (author's transl)]. 1237467 Immun Infekt
Altered expression and localization of creatine kinase B, heterogeneous nuclear ribonucleoprotein F, and high mobility group box 1 protein in the nuclear matrix associated with colon cancer. 16424007 Cancer Res
Assessing the statistical significance of the achieved classification error of classifiers constructed using serum peptide profiles, and a prescription for random sampling repeated studies for massive high-throughput genomic and proteomic studies. 19305632 Cancer Inform
Association of polymorphisms in the cyclin D1 and XPD genes and susceptibility to cancers of the upper aero-digestive tract. 15754315 Mol Carcinog
Association of the DNA repair gene XPD Asp312Asn polymorphism with p53 gene mutations in tobacco-related non-small cell lung cancer. 12844488 Carcinogenesis
Autoantibody profiles reveal ubiquilin 1 as a humoral immune response target in lung adenocarcinoma. 17409457 Cancer Res
Characterization of amplifiable, circulating RNA in plasma and its potential as a tool for cancer diagnostics. 14718398 Clin Chem
Colon cancer specific nuclear matrix protein alterations in human colonic adenomatous polyps. 14743395 J Cell Biochem
Diagnostic accuracy of MALDI mass spectrometric analysis of unfractionated serum in lung cancer. 17909350 J Thorac Oncol
Early detection of head and neck cancer: development of a novel screening tool using multiplexed immunobead-based biomarker profiling. 17220337 Cancer Epidemiol Biomarkers Prev
Early identification of individuals with prostate cancer in negative biopsies. 15017188 J Urol
Evaluation of serum protein profiling by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry for the detection of prostate cancer: I. Assessment of platform reproducibility. 15613711 Clin Chem
Feature Selection for Classification of SELDI-TOF-MS Proteomic Profiles. 16309341 Appl Bioinformatics
Frequent expression of Niban in head and neck squamous cell carcinoma and squamous dysplasia. 19536772 Head Neck
Gastrin-releasing peptide receptor-mediated autocrine growth in squamous cell carcinoma of the head and neck. 11880476 J Natl Cancer Inst
Identification of calreticulin as a nuclear matrix protein associated with human colon cancer. 12704787 J Cell Biochem
Identification of nuclear matrix protein alterations associated with human colon cancer. 11956108 Cancer Res
Initial analyses of colon cancer-specific antigen (CCSA)-3 and CCSA-4 as colorectal cancer-associated serum markers. 17575123 Cancer Res
Intersession reproducibility of mass spectrometry profiles and its effect on accuracy of multivariate classification models. 17766268 Bioinformatics
Mitogenic effects of gastrin-releasing peptide in head and neck squamous cancer cells are mediated by activation of the epidermal growth factor receptor. 13679857 Oncogene
Multianalyte profiling of serum cytokines for detection of pancreatic cancer. 17192050 Cancer Biomark
Multiple cytokine and growth factor serum biomarkers predict therapeutic response and survival in advanced-stage head and neck cancer patients. 17545511 Clin Cancer Res
Multiplexed analysis of serum cytokines as biomarkers in squamous cell carcinoma of the head and neck patients. 15744170 Laryngoscope
No association between the XPD 312, 751, or XRCC1 399 polymorphisms and K-ras gene mutation in smoking non-small-cell lung cancer. 15066937 Cancer Epidemiol Biomarkers Prev
SELDI-TOF MS whole serum proteomic profiling with IMAC surface does not reliably detect prostate cancer. 18024530 Clin Chem
Serum protein expression profiling for cancer detection: validation of a SELDI-based approach for prostate cancer. 15258333 Dis Markers
SRC family kinases mediate epidermal growth factor receptor ligand cleavage, proliferation, and invasion of head and neck cancer cells. 15342401 Cancer Res


Research Interests
Dr. Bigbee’s research activities are focused on the development and validation of cancer early detection and diagnostic molecular markers for application in cancer molecular epidemiology population-based screening and clinical research studies. To facilitate this translational cancer research, Dr. Bigbee is appointed as a Staff Investigator and Director of the Clinical Proteomics Facility in the University of Pittsburgh Cancer Institute (UPCI) and maintains related UPCI programmatic appointments as Leader, Molecular Biomarkers Group, Cancer Epidemiology Program, and as a member of the Head and Neck, and Lung and Thoracic Malignancies Programs. His research expertise is centered in clinical proteomics with EDRN, SPORE and additional NCI/DoD funding support to assess the diagnostic performance of lung cancer-specific protein expression profiles in serum and the use of MALDI-TOF and related mass spectrometry technologies for serum protein expression profiling analysis for early detection of breast, endometrial, head & neck, ovarian, pancreatic, and prostate cancer. Lastly, Dr. Bigbee is the Director of the UPCI Clinical Proteomics Facility, a new UPCI-supported shared resource focused on the development and application of proteomic profiling technology, including Luminex Multianalyte Profiling (LabMAP) for cancer early detection and screening and molecular diagnosis, prognosis, and classification of human tumors.

To update protocols, publications, biomarkers, or science data, please contact the Data Management and Coordinating Center.

Photograph of Bigbee, William L.
University of Pittsburgh Cancer Institute
Person ID
EDRN Title
EDRN Associate Member
To update contact information, please visit the Data Management and Coordinating Center .