US-Turkey Cappadocia Mesothelioma Project

Abbreviated Name
Lead Investigator
Pass, Harvey IraNew York University School of Medicine
Coordinating Investigator
Feng, Ziding Fred Hutchinson Cancer Center
Involved Investigators


We propose to test prospectively the sensitivity and specificity of cell free serum levels of SMRP in the high-risk mesothelioma cohort of Cappadocia. This study would represent a collaboration between the Turkish Ministry of Health and the National Cancer Institute of the United States represented by the University of Hawaii (Michele Carbone MD, PhD), the Early Detection Research Network (EDRN) Mesothelioma Discovery Laboratory of NYU (Harvey Pass MD), and the Data Management and Coordinating Center (DMCC) of EDRN. This prospective study will be conducted in the Cappadocian villages for the following reasons: 1. In these villages there is a unique very high incidence of mesothelioma never seen in any other part of the world. The very high mesothelioma incidence will allow us to obtain biomarker data in a relatively short time at a fraction of the costs required to follow a sufficiently large cohort in the USA that would produce the same incidence. The incidence of mesothelioma in the Western World is about 1-2/106 individuals; in the Cappadocian villages is about 1.5/100. 2. The preliminary results demonstrate the feasibility of the study. 3. Drs. Carbone and Pass have a proven track record of working with this cohort; moreover, they have the full support of Dr. Murat Tuncer, who is the Director of the Office of Cancer Control at the Turkish Ministry of Health, and who oversees blood collection performed by Turkish physicians and plans to open a Mesothelioma Clinic in the Turkish village to conduct this research.


study never launched

Analytic Method

study never launched


  • No biomarkers available at this time for this protocol

Data Collections

  • No data available at this time for this protocol
Protocol ID
Protocol Type
Field of Research
Collaborative Group
Lung and Upper Aerodigestive Cancers Research Group
Cancer Types
  • Malignant neoplasm of bronchus and lung

Associated Forms