Aliases

• 8-Hydroxyguanine DNA Glycosylase
• 8-oxoguanine DNA glycosylase
• AP Lyase
• DNA-Apurinic Or Apyrimidinic Site Lyase
• HMMH
• HOGG1
• MMH
• MUTM
• N-Glycosylase/DNA Lyase
• OGG1
• OGG1 Type 1d
• OGG1 Type 1e
• OGG1 Type 1f
• OGG1 Type 1g
• OGG1 Type 1h
• OGH1

Description

8-Oxoguanine DNA Glycosylase, or OGG1, is a DNA repair enzyme that removes both 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. OGG1 has a beta-lyase activity that nicks DNA 3' to the lesion. There are two major groups of splice variants for this gene, classified by alternative splicing of the C-terminal region of the gene, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization.

Attributes

QA State

Curated

Type

Protein

HGNC Name

OGG1