The long noncoding RNA SChLAP1 promotes aggressive prostate cancer and antagonizes the SWI/SNF complex.

Abstact

Prostate cancers remain indolent in the majority of individuals but behave aggressively in a minority. The molecular basis for this clinical heterogeneity remains incompletely understood. Here we characterize a long noncoding RNA termed SChLAP1 (second chromosome locus associated with prostate-1; also called LINC00913) that is overexpressed in a subset of prostate cancers. SChLAP1 levels independently predict poor outcomes, including metastasis and prostate cancer-specific mortality. In vitro and in vivo gain-of-function and loss-of-function experiments indicate that SChLAP1 is critical for cancer cell invasiveness and metastasis. Mechanistically, SChLAP1 antagonizes the genome-wide localization and regulatory functions of the SWI/SNF chromatin-modifying complex. These results suggest that SChLAP1 contributes to the development of lethal cancer at least in part by antagonizing the tumor-suppressive functions of the SWI/SNF complex.

Biomarkers

One biomarker makes reference to this publication:

Authors
  • Asangani IA
  • Bedenis R
  • Cao Q
  • Cao X
  • Chandler B
  • Chen W
  • Chinnaiyan AM
  • Davicioni E
  • Dhanasekaran SM
  • Erho N
  • Feng FY
  • Ghadessi M
  • Han S
  • Iyer MK
  • Jenkins RB
  • Jing X
  • Kunju LP
  • Ma T
  • Malik R
  • McGregor N
  • Patel L
  • Pienta KJ
  • Prensner JR
  • Sahu A
  • Siddiqui J
  • Triche TJ
  • Vergara IA
  • Wang X
  • Yan W
PubMed ID
Appears In
Nat Genet, 2013, 45 (11)