A mouse plasma peptide atlas as a resource for disease proteomics.
Abstact
We present an in-depth analysis of mouse plasma leading to the development of a publicly available repository composed of 568 liquid chromatography-tandem mass spectrometry runs. A total of 13,779 distinct peptides have been identified with high confidence. The corresponding approximately 3,000 proteins are estimated to span a 7 logarithmic range of abundance in plasma. A major finding from this study is the identification of novel isoforms and transcript variants not previously predicted from genome analysis.
Authors
- Aebersold R
- Bardeesy N
- Depinho RA
- Deutsch EW
- Dinulescu D
- Faca VM
- Hanash SM
- Hung KE
- Jacks T
- Kucherlapati R
- Menon R
- Newcomb LF
- Omenn GS
- Pitteri SJ
- Politi K
- States DJ
- Wang H
- Zhang Q