Emerging roles of MUC4 in cancer: a novel target for diagnosis and therapy.


The MUC4 mucin is a transmembrane glycoprotein that is implicated in the pathogenesis of pancreatic cancer and is aberrantly expressed in many other epithelial carcinomas. Recent studies suggest its significant potential as a clinical tool for cancer diagnosis and prognosis. MUC4 modulates HER2/ErbB2 signaling and is a determinant of therapeutic outcome of Herceptin-based therapy, which further indicates its prospective usefulness in cancer therapy and treatment planning.

  • Batra SK
  • Chaturvedi P
  • Singh AP
PubMed ID
Appears In
Cancer Res, 2007, 67 (2)