Hepatitis B virus-mediated changes of apolipoprotein mRNA abundance in cultured hepatoma cells.


An inverse correlation between hepatitis B virus (HBV) and steady-state levels of apolipoprotein AI and CIII mRNAs was observed in two hepatoma cell lines. Analysis of a third line containing an inducible viral genome implicated viral pregenomic RNA in apolipoprotein mRNA reduction. We conclude that HBV alters infected cells despite the absence of overt cytopathogenicity.

  • Block TM
  • Gong Q
  • Lu X
  • Mehta AS
  • Norton PA
PubMed ID
Appears In
J Virol, 2003, 77 (9)