Abbreviated Name

MLDA in pancreatic cancer

Lead Investigator

Lynch, Henry — Creighton University

Coordinating Investigator

No coordinating investigator

Involved Investigators

• Costa, Jose — Yale University School of Medicine
• Lynch, Henry — Creighton University

Abstact

No abstract availalbe.

Aims

No aims available.

Analytic Method

No analytic method available.

Outcome

Certain p16 mutation carriers showed mutation elevations in the specific Ki-ras and p53 alleles significantly higher than normal, similar to controls with pancreatitis. Two individuals from separate families started out with "low risk" readings subsequently converted to "high risk" categorization and remained there in each sequential exam.

Publications

• Mutational load distribution analysis yields metrics reflecting genetic instability during pancreatic carcinogenesis.

Biomarkers

• KRAS

Data Collections

• No data collections available at this time for this protocol.

Finish Date

Jun 1 2004

Protocol ID

82

Protocol Type

Collaboration

Field of Research

UNKNOWN

Collaborative Group

G.I. and Other Associated Cancers Research Group

Cancer Types

• Malignant neoplasm of pancreas