Abbreviated Name

PCA3 Ref Set App: Zhang (2019)

Lead Investigator

Zhang, Hui L. — Johns Hopkins University School of Medicine

Coordinating Investigator

Feng, Ziding — Fred Hutchinson Cancer Center

Involved Investigators

• Feng, Ziding — Fred Hutchinson Cancer Center
• Zhang, Hui L. — Johns Hopkins University School of Medicine

Abstact

see Objectives

Aims

We propose the following two aims: 1. Determine the performance of using urinary glycoproteomics and mass spectrometry for the detection of aggressive prostate cancer. We will (a) validate 4 candidate glycoproteins to detect AG PCa in diagnostic biopsy in the NCI-EDRNs Urinary PCA3 Evaluation Trial: (b) with PCA3 trial samples further develop a glycoproteomic risk score for predicting AG Pca in diagnostic biopsy; (c) validate the utility of glycoproteins separately and in combination to predict prostate cancer with a higher tumor grade (i.e., Gleason 3+4 or greater) at radical prostatectomy with NCI-EDRN Tissue Upgrading cohort. 2. Develop and apply ELISA assays to verify the candidate glycoproteins as non-invasive urinary tests for detecting aggressive prostate cancer.

Analytic Method

Biomarkers

• ACP3
• DSC2
• PTGDS
• TMPRSS2

Data Collections

• No data available at this time for this protocol

 Team Project

Protocol ID

460

Field of Research

Glycomics

Collaborative Group

Prostate and Urologic Cancers Research Group

Cancer Types

• Malignant neoplasm of prostate

Phased Status

2