Abbreviated Name

MSA Bladder Ref Set App: Rosser (2014)

Lead Investigator

Rosser, Charles J — University of Hawaii Cancer Center

Coordinating Investigator

Feng, Ziding — Fred Hutchinson Cancer Center

Involved Investigators

• Feng, Ziding — Fred Hutchinson Cancer Center
• Rosser, Charles J — University of Hawaii Cancer Center

Abstact

Aims

Discovery cohort - 200 DNA samples from exfoliated cells (100 BCa and 100 controls) from a reference set at EDRN will be screened via direct PCR and sequencing for mutations with PAI-1 (promoter and exons 1-9) and ANG (promoter and exons 1-3).

Analytic Method

Mutational analysis will be assessed using Ion Reporter™ Software located in our Genomic Shared Resource. Fisher’s exact test will be used to assess the association of PAI-1 and ANG genetic alterations with clinicopathologic factors or mutations with each other. A P-value of < 0.05 will be considered to be statistically significant.

Biomarkers

• ANG
• APOE
• CA9
• CXCL8
• MMP10
• MMP9
• SDC1
• SERPINA1
• SERPINE1
• VEGFA

Data Collections

• No data available at this time for this protocol

 Team Project

Protocol ID

394

Protocol Type

Reference Set

Field of Research

Genomics

Collaborative Group

Prostate and Urologic Cancers Research Group

Cancer Types

• Malignant neoplasm of bladder