MSA Bladder Reference Set Application: Charles Rosser-Hawaii (2014)
- Abbreviated Name
- MSA Bladder Ref Set App: Rosser (2014)
- Lead Investigator
- Rosser, Charles J — University of Hawaii Cancer Center
- Coordinating Investigator
- Feng, Ziding — Fred Hutchinson Cancer Center
- Involved Investigators
Abstact
Aims
Discovery cohort - 200 DNA samples from exfoliated cells (100 BCa and 100 controls) from a reference set at EDRN will be screened via direct PCR and sequencing for mutations with PAI-1 (promoter and exons 1-9) and ANG (promoter and exons 1-3).
Analytic Method
Mutational analysis will be assessed using Ion Reporter™ Software located in our Genomic Shared Resource. Fisher’s exact test will be used to assess the association of PAI-1 and ANG genetic alterations with clinicopathologic factors or mutations with each other. A P-value of < 0.05 will be considered to be statistically significant.
Biomarkers
Data Collections
- No data available at this time for this protocol
Team Project
- Protocol ID
- 394
- Protocol Type
- Reference Set
- Field of Research
- Genomics
- Collaborative Group
- Prostate and Urologic Cancers Research Group
- Cancer Types
-
- Malignant neoplasm of bladder