Abbreviated Name

MSA Bladder Ref Set App: Rosser (2014)

Lead Investigator

Rosser, Charles J — University of Hawaii Cancer Center

Coordinating Investigator

Feng, Ziding — Fred Hutchinson Cancer Center

Involved Investigators

• Feng, Ziding — Fred Hutchinson Cancer Center
• Rosser, Charles J — University of Hawaii Cancer Center

Abstact

Aims

Discovery cohort - 200 DNA samples from exfoliated cells (100 BCa and 100 controls) from a reference set at EDRN will be screened via direct PCR and sequencing for mutations with PAI-1 (promoter and exons 1-9) and ANG (promoter and exons 1-3).

Analytic Method

Mutational analysis will be assessed using Ion Reporter™ Software located in our Genomic Shared Resource. Fisher’s exact test will be used to assess the association of PAI-1 and ANG genetic alterations with clinicopathologic factors or mutations with each other. A P-value of < 0.05 will be considered to be statistically significant.

Biomarkers

• ANG
• APOE
• CA9
• CXCL8
• MMP10
• MMP9
• SDC1
• SERPINA1
• SERPINE1
• VEGFA

Data Collections

• No data available at this time for this protocol

 Team Project

Protocol ID

394

Field of Research

Genomics

Collaborative Group

Prostate and Urologic Cancers Research Group

Cancer Types

• Malignant neoplasm of bladder