Lung Reference Set A Application: Dawn Coverley- University of York (2011)

Abbreviated Name
Lung Ref Set A App: Coverley (2011)
Lead Investigator
Coverley, DawnUniversity of York
Coordinating Investigator
Feng, Ziding Fred Hutchinson Cancer Center
Involved Investigators

Abstact

Aims

There are four primary clinical questions to be addressed in the pre-validation study: 1) Whether b-variant Ciz1 as a single plasma biomarker has the potential for adding value to current clinical tests (CT scan and/or PET scan) in the diagnostic evaluation of pulmonary nodules with a goal of reducing invasive tests (PET or tissue biopsy) or futile thoracotomies; 2) Whether b-variant Ciz1 as a single plasma biomarker has the potential for adding value to current tests (CT scan and/or PET scan) in the early diagnosis/detection of lung cancer in high risk individuals, with a goal of reducing invasive tests (PET or tissue biopsy) or futile thoracotomies and more importantly, missed cures; and 3) Whether b-variant Ciz1 as a single plasma biomarker has the potential for adding value to current clinical tests (CT scan, PET scan and biopsies) in the staging of lung cancer; and, 4) Whether b-variant Ciz1 as a single plasma biomarker has the potential for adding value to current clinical tests (e.g., CT scan, PET scan and biopsies) in determining prognosis of lung cancer patients; and, A Secondary clinical question is whether b-variant Ciz1 as part of a panel of biomarkers has the potential for adding value to one or more of the above primary clinical utilities.

Analytic Method

Provide adequate detail concerning how statistical analysis of your data generated from the Reference Set(s) samples will be performed and a justification that the requested References Set(s) is/are large enough to demonstrate the utility of the biomarker. Describe the statistical resources at your disposal. If you require statistical support, the EDRN/SPOREs can assist you with this.

Comments

No Data Received at DMCC. Assay didn't work well on the samples provided.

Biomarkers

Data Collections

  • No data collections available at this time for thie protocol
Protocol ID
341
Protocol Type
Reference Set
Field of Research
Proteomics
Collaborative Group
Lung and Upper Aerodigestive Cancers Research Group
Cancer Types
  • Malignant neoplasm of bronchus and lung
Phased Status
1

Associated Forms