Abbreviated Name

Liver Rapid Ref Set App: Qu (2011)

Lead Investigator

Qu, Kevin — Quest Diagnostics

Coordinating Investigator

Feng, Ziding — Fred Hutchinson Cancer Center

Involved Investigators

• Feng, Ziding — Fred Hutchinson Cancer Center
• Srivastava, Sudhir — National Cancer Institute
• Qu, Kevin — Quest Diagnostics

Abstact

Aims

We propose to evaluate the performance of a novel serum biomarker panel for early detection of hepatocellular carcinoma (HCC).

Analytic Method

In the proposed study, we will not need a training set in addition to a blinded reference set. The HCC UPS model was selected from a working set that included patients with HCC (n=135), and CLD with cirrhosis (F3-4, n=148), with samples randomly assigned into 100 training sets and testing sets. The model was created using these training sets and evaluated in the testing sets by averaged error rates and area under the ROC (AUROC) curve analysis. The blinded reference set is designed to confirm the utility of the HCC UPS model. Our statisticians will perform all statistic analysis; Dr. Michael Walker, a professor at Stanford University, will monitor the statistical analysis. We will not need help from the EDRN if we do a larger Phase II validation study.

Biomarkers

• AFP
• AFP-L3
• DCP

Data Collections

• No data available at this time for this protocol

Protocol ID

329

Protocol Type

Reference Set

Field of Research

Proteomics

Collaborative Group

G.I. and Other Associated Cancers Research Group

Cancer Types

• Liver cell carcinoma

Phased Status

1