Liver Rapid Reference Set Application: Kevin Qu-Quest (2011)

Abbreviated Name
Liver Rapid Ref Set App: Qu (2011)
Lead Investigator
Qu, KevinQuest Diagnostics
Coordinating Investigator
Feng, Ziding Fred Hutchinson Cancer Center
Involved Investigators

Abstact

No abstract availalbe.

Aims

We propose to evaluate the performance of a novel serum biomarker panel for early detection of hepatocellular carcinoma (HCC).

Analytic Method

In the proposed study, we will not need a training set in addition to a blinded reference set. The HCC UPS model was selected from a working set that included patients with HCC (n=135), and CLD with cirrhosis (F3-4, n=148), with samples randomly assigned into 100 training sets and testing sets. The model was created using these training sets and evaluated in the testing sets by averaged error rates and area under the ROC (AUROC) curve analysis. The blinded reference set is designed to confirm the utility of the HCC UPS model. Our statisticians will perform all statistic analysis; Dr. Michael Walker, a professor at Stanford University, will monitor the statistical analysis. We will not need help from the EDRN if we do a larger Phase II validation study.

Publications

  • No publications available at this time for this protocol.

Biomarkers

Data Collections

  • No data collections available at this time for this protocol.
Start Date
Feb 28 2011
Estimated Finish Date
Jun 28 2011
Finish Date
Feb 28 2011
Protocol ID
329
Protocol Type
Reference Set
Field of Research
Proteomics
Collaborative Group
G.I. and Other Associated Cancers Research Group
Cancer Types
  • Liver cell carcinoma
Phased Status
1

Associated Forms