Lung Reference Set A Application: LaszloTakacs - Biosystems (2010)
- Abbreviated Name
- Lung Ref Set A App: Takacs (2010)
- Lead Investigator
- Takacs, Laszlo — Biosystems International SAS
- Coordinating Investigator
- Feng, Ziding — Fred Hutchinson Cancer Center
- Involved Investigators
Abstact
Aims
Validate the panel of monoclonal antibodies
Analytic Method
To complete the research phase of the project, we refine our algorithm. From this experiment, we will select the final panel of antibodies which will be used to develop the final diagnostic test. This final panel of antibodies used is selected as the panel showing the highest discrimination between the two groups (control vs. lung cancer). A learning algorithm based on LDA (Linear Discrimination Analysis) model is applied on each potential panel (called classifiers) and the performance of each classifier is evaluated calculating the AUC (area under the receiver operating curve) by Leave-One-Out-Cross validation (LOOCV). With the refined algorithm, we would like to test the Combined Pre-Validation Set A of the NCI lung cancer reference set.
Biomarkers
Data Collections
- No data available at this time for this protocol
Team Project
- Protocol ID
- 321
- Protocol Type
- Reference Set
- Field of Research
- Proteomics
- Collaborative Group
- Lung and Upper Aerodigestive Cancers Research Group
- Cancer Types
-
- Malignant neoplasm of bronchus and lung
- Phased Status
- 1