Abbreviated Name

Lung Ref Set A App: Takacs (2010)

Lead Investigator

Takacs, Laszlo — Biosystems International SAS

Coordinating Investigator

Feng, Ziding — Fred Hutchinson Cancer Center

Involved Investigators

• Feng, Ziding — Fred Hutchinson Cancer Center
• Srivastava, Sudhir — National Cancer Institute
• Takacs, Laszlo — Biosystems International SAS

Abstact

Aims

Validate the panel of monoclonal antibodies

Analytic Method

To complete the research phase of the project, we refine our algorithm. From this experiment, we will select the final panel of antibodies which will be used to develop the final diagnostic test. This final panel of antibodies used is selected as the panel showing the highest discrimination between the two groups (control vs. lung cancer). A learning algorithm based on LDA (Linear Discrimination Analysis) model is applied on each potential panel (called classifiers) and the performance of each classifier is evaluated calculating the AUC (area under the receiver operating curve) by Leave-One-Out-Cross validation (LOOCV). With the refined algorithm, we would like to test the Combined Pre-Validation Set A of the NCI lung cancer reference set.

Biomarkers

• BSI panel (mAb)
• SW1 (mAb)
• SW2 (mAb)
• SW3 (mAb)
• SW4 (mAb)

Data Collections

• No data available at this time for this protocol

 Team Project

Protocol ID

321

Protocol Type

Reference Set

Field of Research

Proteomics

Collaborative Group

Lung and Upper Aerodigestive Cancers Research Group

Cancer Types

• Malignant neoplasm of bronchus and lung

Phased Status

1