Lung Reference Set A Application: LaszloTakacs - Biosystems (2010)

Abbreviated Name
Lung Ref Set A App: Takacs (2010)
Lead Investigator
Takacs, LaszloBiosystems International SAS
Coordinating Investigator
Feng, Ziding Fred Hutchinson Cancer Center
Involved Investigators


No abstract availalbe.


Validate the panel of monoclonal antibodies

Analytic Method

To complete the research phase of the project, we refine our algorithm. From this experiment, we will select the final panel of antibodies which will be used to develop the final diagnostic test. This final panel of antibodies used is selected as the panel showing the highest discrimination between the two groups (control vs. lung cancer). A learning algorithm based on LDA (Linear Discrimination Analysis) model is applied on each potential panel (called classifiers) and the performance of each classifier is evaluated calculating the AUC (area under the receiver operating curve) by Leave-One-Out-Cross validation (LOOCV). With the refined algorithm, we would like to test the Combined Pre-Validation Set A of the NCI lung cancer reference set.


We would like to access the NCI lung cancer Combined Pre-Validation Reference Set A in order to further validate a lung cancer diagnostic test candidate. Our test is based on a panel of antibodies which have been tested on 4 different cohorts (see below, paragraph “Preliminary Data and Methods”). This Reference Set A, whose clinical setting is “Diagnosis of lung cancer”, will be used to validate the panel of monoclonal antibodies which have been demonstrated by extensive data analysis to provide the best discrimination between controls and Lung Cancer patient plasma samples, sensitivity and specificity values from ROC analyses are superior than 85 %.


  • No publications available at this time for this protocol.


Data Collections

  • No data collections available at this time for this protocol.
 Team Project
Start Date
Aug 24 2010
Estimated Finish Date
Dec 24 2010
Finish Date
Feb 27 2012
Protocol ID
Protocol Type
Reference Set
Field of Research
Collaborative Group
Lung and Upper Aerodigestive Cancers Research Group
Cancer Types
  • Malignant neoplasm of bronchus and lung
Phased Status

Associated Forms