Lung Reference Set A Application: Edward Hirschowitz - University of Kentucky (2009)
- Abbreviated Name
- Lung Ref Set A App: Hirschowitz (2009)
- Lead Investigator
- Hirschowitz, Edward — University of Kentucky
- Coordinating Investigator
- Feng, Ziding — Fred Hutchinson Cancer Center
- Involved Investigators
Abstact
Aims
Aim 1. To pre-validate assay performance in a high-risk clinical population from an alternate demographic. We intend to validate the predictive accuracy of our markers for clinically diagnosed lung cancer, identify the limits of the assay in individuals with benign lung disease, and determine marker specificity for lung vs. other cancers. Pre-validation will define performance in samples from an alternate demographic and generate classifiers with which to construct optimalperformance criteria that can be applied to class prediction for subsequent blinded analysis of a larger EDRN clinical reference set.
Analytic Method
Assay. The diagnostic chip includes capture proteins for the most predictive markers and empty T7 phage controls in replicates of eight, randomly distributed across the chip. The methodology for all studies will be identical to that described in published manuscripts and preliminary results section.
Biomarkers
Data Collections
- No data available at this time for this protocol
- Protocol ID
- 279
- Protocol Type
- Reference Set
- Field of Research
- Proteomics
- Collaborative Group
- Lung and Upper Aerodigestive Cancers Research Group
- Cancer Types
-
- Malignant neoplasm of bronchus and lung
- Phased Status
- 1