VTCN1
- Aliases
-
- B7 family member, H4
- B7 superfamily member 1
- B7-H4
- B7H4
- B7S1
- B7X
- B7h.5
- DD-0110
- FLJ22418
- Immune costimulatory protein B7-H4
- OV110
- PRO1291
- Protein B7S1
- T-cell costimulatory molecule B7x
- V-set domain containing T cell activation inhibitor 1
- VCTN1
- VTCN1
- Description
- Highly glycosylated sialomucin; expressed on immune cells. Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation. Overexpressed in breast, ovarian, endometrial, renal cell (RCC) and non-small-cell lung cancers (NSCLC). Belongs to the B7 family of costimulatory proteins.
Attributes
- QA State
- Accepted
- Type
- Protein
- HGNC Name
- VTCN1
- Certifications
-
- None
- QA State for Ovary
- Accepted
Organ-Specific Notes
Genomic analysis revealed upregulation in breast and ovarian epithelial tumors; protein overexpression studies confirmed finding.
Performance Comment
Of the 28 ovarian cancer biomarkers tested in prediagnostic specimens, from the PLCO, CA125 remains the the single best biomarker for ovarian cancer and has its strongest signal within six months of diagnosis. B7-H4 alone was not a strong predictor.
Supporting Study Data
PLCO Ovarian Phase III Validation Study
SPORE/EDRN/PRE-PLCO Ovarian Phase II Validation Study
Ovary-Specific Protocols
- No organ-level protocols specified for ovary.
Ovary-Specific Publications
- No organ-level publications were listed for ovary.
Ovary-Specific Resources
- No organ-level resources were given for ovary.
- A framework for evaluating biomarkers for early detection: validation of biomarker panels for ovarian cancer.
- B7-h4 is a novel membrane-bound protein and a candidate serum and tissue biomarker for ovarian cancer.
- Ovarian cancer biomarker performance in prostate, lung, colorectal, and ovarian cancer screening trial specimens.
- HGNC entry 28873 forV-set domain containing T cell activation inhibitor 1 (VTCN1), also called B7-H4,FLJ22418, B7S1, B7X, B7H4
- Human Protein Atlas entry for human VTCN1 (B7-H4)
- KEGG entry 79679 for V-set domain containing T cell activation inhibitor 1 (VTCN1), also called B7-H4
- UniProtKB/Swiss-Prot entry Q7Z7D3 for VTCN1_HUMAN, also called Immune costimulatory protein B7-H4