SLPI
- Aliases
-
- ALK1
- ALP
- BLPI
- HUSI
- HUSI-I
- MPI
- Mucus proteinase inhibitor
- SLPI
- Seminal proteinase inhibitor
- WAP four-disulfide core domain protein 4
- WAP4
- WFDC4
- antileukoproteinase
- secretory leukocyte peptidase inhibitor
- secretory leukocyte protease inhibitor (antileukoproteinase)
- Description
- From NCBI Gene: This gene encodes a secreted inhibitor which protects epithelial tissues from serine proteases. It is found in various secretions including seminal plasma, cervical mucus, and bronchial secretions, and has affinity for trypsin, leukocyte elastase, and cathepsin G. Its inhibitory effect contributes to the immune response by protecting epithelial surfaces from attack by endogenous proteolytic enzymes. This antimicrobial protein has antibacterial, antifungal and antiviral activity. [provided by RefSeq, Nov 2014]
Attributes
- QA State
- Curated
- Type
- Protein
- HGNC Name
- SLPI
- Certifications
-
- None
- QA State for Breast
- Under Review
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
- Certifications
-
- None
- QA State for Lung
- Under Review
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
- Certifications
-
- None
- QA State for Ovary
- Curated
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
- Certifications
-
- None
- QA State for Prostate
- Under Review
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
- A framework for evaluating biomarkers for early detection: validation of biomarker panels for ovarian cancer.
- A targeted proteomics-based pipeline for verification of biomarkers in plasma.
- Expression profiling identifies genes involved in neoplastic transformation of serous ovarian cancer.
- Ovarian cancer biomarker performance in prostate, lung, colorectal, and ovarian cancer screening trial specimens.
- Use of an immunoaffinity-mass spectrometry-based approach for the quantification of protein biomarkers from serum samples of lung cancer patients.
- Entrez Protein Reference Sequence for human SLPI secretory leukocyte peptidase inhibitor
- HGNC entry for human secretory leukocyte peptidase inhibitor SLPI
- KEGG entry for human secretory leukocyte peptidase inhibitor SLPI
- NCBI Gene entry for human SLPI
- UniProtKB/Swiss-Prot entry for P03973 (SLPI_HUMAN)
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.