RARB
- Aliases
-
- HAP
- HBV-activated protein
- NR1B2
- Nuclear receptor subfamily 1 group B member 2
- RAR-beta
- RAR-epsilon
- RARB
- RRB2
- hepatitis B virus activated protein
- retinoic acid receptor beta
- retinoic acid receptor beta 2
- retinoic acid receptor beta 4
- retinoic acid receptor beta 5
- retinoic acid receptor beta variant 1
- retinoic acid receptor beta variant 2
- retinoic acid receptor, beta
- retinoic acid receptor, beta polypeptide
- Description
- The RARB gene encodes the retinoic acid receptor beta. It is a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators (NRB1 class). These receptors bind to their targets as heterodimers in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. This receptor localizes to the cytoplasm and to subnuclear compartments where it binds retinoic acid, the biologically active form of vitamin A which mediates cellular signalling in embryonic morphogenesis, cell growth and differentiation. It is thought that the RARB protein limits growth of many cell types by regulating gene expression. There are three distinct RAR subtypes; RARalpha, RARbeta and RARgamma. RARalpha is present in most tissue types, whereas RARbeta and RARgamma expression is more selective. Two full length transcript variants have been verified. A third is possible.
Attributes
- QA State
- Under Review
- Type
- Gene
- HGNC Name
- RARB
- Certifications
-
- None
- QA State for Lung
- Under Review
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.