Aliases

• CD148
• CD148 Antigen
• DEP-1
• DEP1
• Density-Enhanced Phosphatase 1
• HPTP Eta
• HPTPeta
• Human Density Enhanced Phosphatase-1
• PTPRJ
• Protein Tyrosine Phosphatase Receptor Type J
• Protein Tyrosine Phosphatase, Receptor Type, J Polypeptide
• Protein-Tyrosine Phosphatase Eta
• Protein-Tyrosine Phosphatase Receptor Type J
• R-PTP-ETA
• R-PTP-Eta
• R-PTP-J
• Receptor-Type Tyrosine-Protein Phosphatase Eta
• SCC1
• Susceptibility To Colon Cancer 1, Mouse, Homolog Of

Description

From NCBI Gene: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This protein is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Attributes

QA State

Under Review

Type

Protein

HGNC Name

PTPRJ