pleiotrophin

Aliases:
This biomarker is also known as:
  • OSF-1
  • HBGF-8
  • HBNF1
  • Heparin-binding growth-associated molecule
  • heparin binding growth factor 8
  • heparin-binding neurite outgrowth-promoting factor 1
  • HARP
  • HBBM
  • heparin affin regulatory protein
  • HB-GAM
  • heparin-binding growth-associated molecule
  • HBNF-1
  • HBNF
  • osteoblast-specific factor 1
  • Heparin-binding neurite outgrowth-promoting factor 1
  • pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1)
  • heparin-binding brain mitogen
  • Heparin-binding brain mitogen
  • PTN
  • neurite growth-promoting factor 1
  • Osteoblast-specific factor 1
  • pleiotrophin
  • heparin-binding growth factor 8
  • Heparin-binding growth factor 8
  • NEGF1
  • HBGF8

Description…

Pleiotrophin, or PTN, is a secreted growth factor found in osteoblasts and brain tissue. PTN induces neurite outgrowth and is mitogenic for fibroblasts, epithelial, and endothelial cells. It binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation.

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Curated
Type: Protein
HGNC Name: PTN

The following organs have data associated with this biomarker…

Attributes

Phase: 2
QA State: Curated
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access to this biomarker.

Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access to this biomarker.

Version 5.1.0