PRKCI
- Aliases
-
- Atypical protein kinase C-lambda/iota
- DXS1179E
- EC 2.7.11.13
- PKCI
- PRKC-lambda/iota
- PRKCI
- aPKC-lambda/iota
- atypical protein kinase C-lambda/iota
- nPKC-iota
- protein kinase C iota type
- protein kinase C, iota
- Description
- PRKCI is a member of the protein kinase C (PKC) family of serine/threonine protein kinases. It is a calcium- and diacylglycerol-independent serine/threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis.
Attributes
- QA State
- Curated
- Type
- Protein
- HGNC Name
- PRKCI
- Certifications
-
- None
- QA State for Lung
- Curated
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.