PPBP
- Aliases
-
- B-TG1
- Beta-TG
- CTAP-III
- CTAP3
- CTAPIII
- CXC chemokine ligand 7
- CXCL7
- LA-PF4
- LDGF
- MDGF
- NAP-2
- NAP-2-L1
- PBP
- PPBP
- SCYB7
- TC1
- TC2
- TGB
- TGB1
- THBGB
- THBGB1
- b-TG1
- beta-thromboglobulin
- connective tissue-activating peptide III
- leukocyte-derived growth factor
- low-affinity platelet factor IV
- macrophage-derived growth factor
- neutrophil-activating peptide 2
- neutrophil-activating peptide-2
- platelet basic protein
- pro-platelet basic protein
- pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
- small inducible cytokine B7
- small inducible cytokine subfamily B, member 7
- thrombocidin 1
- thrombocidin 2
- thromboglobulin, beta-1
- Description
- CTAP-III (officially named PPBP) is a platelet-derived growth factor that belongs to the CXC chemokine family. This growth factor is a potent chemoattractant and activator of neutrophils. It has been shown to stimulate various cellular processes including DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and sythesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by synovial cells.
Attributes
- QA State
- Curated
- Type
- Protein
- HGNC Name
- PPBP
- Certifications
-
- None
- QA State for Ovary
- Curated
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
- A framework for evaluating biomarkers for early detection: validation of biomarker panels for ovarian cancer.
- Ovarian cancer biomarker performance in prostate, lung, colorectal, and ovarian cancer screening trial specimens.
- Proteomic biomarkers in combination with CA 125 for detection of epithelial ovarian cancer using prediagnostic serum samples from the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial.
- HGNC entry for human pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) PPBP
- KEGG entry for human pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) PPBP
- Protein Reference Sequence for platelet basic protein preproprotein [Homo sapiens]
- UniProtKB/Swiss-Prot entry for P02775 (CXCL7_HUMAN)
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.