OAS1

Aliases
  • (2-5')oligo(A) synthase 1
  • (2-5')oligo(A) synthetase 1
  • 2',5'-oligo A synthetase 1
  • 2',5'-oligoadenylate synthetase 1 (40-46 kD)
  • 2',5'-oligoadenylate synthetase 1, 40/46kDa
  • 2'-5' oligoadenylate synthetase 1 p48 isoform
  • 2'-5' oligoadenylate synthetase 1 p52 isoform
  • 2'-5'-oligoadenylate synthase 1
  • 2'-5'-oligoadenylate synthetase 1, 40/46kDa
  • 2'-5'-oligoisoadenylate synthetase 1
  • 2-5A synthase 1
  • 2-5A synthetase 1
  • E18/E16
  • EC 2.7.7.-
  • IFI-4
  • OAS1
  • OIAS
  • OIASI
  • p46/p42 OAS
Description
From NCBI Gene: This gene is induced by interferons and encodes a protein that synthesizes 2',5'-oligoadenylates (2-5As). This protein activates latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. Alternative splicing results in multiple transcript variants with different enzymatic activities. Polymorphisms in this gene have been associated with susceptibility to viral infection and diabetes mellitus, type 1. A disease-associated allele in a splice acceptor site influences the production of the p46 splice isoform. This gene is located in a cluster of related genes on chromosome 12. [provided by RefSeq, Feb 2016]
Attributes
QA State
Under Review
Type
Proteomic
HGNC Name
OAS1
Certifications
  • None
QA State for Breast
Under Review

 Non-Public Biomarker

Organ-specific information for some biomarkers are currently being annotated or are "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.

Certifications
  • None
QA State for Prostate
Under Review

 Non-Public Biomarker

Organ-specific information for some biomarkers are currently being annotated or are "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.

 Non-Public Biomarker

Organ-specific information for some biomarkers are currently being annotated or are "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.

 Non-Public Biomarker

Organ-specific information for some biomarkers are currently being annotated or are "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.

 Non-Public Biomarker

Organ-specific information for some biomarkers are currently being annotated or are "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.

 Non-Public Biomarker

Organ-specific information for some biomarkers are currently being annotated or are "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.