Aliases

• N2N
• NOTCH2NL
• NOTCH2NLA
• Notch 2 N-Terminal Like
• Notch 2 N-Terminal Like A
• Notch Homolog 2 (Drosophila) N-Terminal Like
• Notch Homolog 2 N-Terminal Like Protein
• Notch Homolog 2 N-Terminal-Like Protein
• Notch Homolog 2 N-Terminal-Like Protein A

Description

From UniProtKB: Human-specific protein that promotes neural progenitor proliferation and evolutionary expansion of the brain neocortex by regulating the Notch signaling pathway (PubMed:29856954, PubMed:29856955, PubMed:29561261). Able to promote neural progenitor self-renewal, possibly by down-regulating neuronal differentiation genes, thereby delaying the differentiation of neuronal progenitors and leading to an overall final increase in neuronal production (PubMed:29856954). Acts by enhancing the Notch signaling pathway via two different mechanisms that probably work in parallel to reach the same effect (PubMed:29856954). Enhances Notch signaling pathway in a non-cell-autonomous manner via direct interaction with NOTCH2 (PubMed:29856954). Also promotes Notch signaling pathway in a cell-autonomous manner through inhibition of cis DLL1-NOTCH2 interactions, which promotes neuronal differentiation (By similarity).

Attributes

QA State

Under Review

Type

Protein

HGNC Name

NOTCH2NLA