NELL1

Aliases
  • NEL-like protein 1
  • NELL1
  • NRP1
  • Nel-related protein 1
  • Protein kinase C-binding protein NELL1
  • nel-like 1
Description
NELL1 is a cytoplasmic protein that contains epidermal growth factor (EGF)-like repeats. The encoded heterotrimeric protein may be involved in cell growth regulation and differentiation.
Attributes
QA State
Accepted
Type
Genomic
HGNC Name
NELL1
Certifications
  • None
QA State for Esophagus
Accepted
Organ-Specific Notes

Esphageal adenocarcinoma risk in Barrett's esophagus is increased 30- to 125- fold versus the general population. Among all Barrett's esophagus patients neoplastic progression occurs only once per 200 patient-years. Molecular markers (individual or in panel) would be useful to risk-stratify patients for more efficient surveillance endoscopy and to improve the early detection of progression.

Performance Comment

Promoter hypermethylation of NELL1 occurs early during Barrett's-associated esophageal neoplastic progression, and is a potential biomarker of poor prognosis in early-stage esophageal adenocarcinoma. Studies are ongoing.

Supporting Study Data
Barretts Esophagus Methylation Profiles
Study phase on the esophagus: 3

We propose a nested case-control study of biomarkers in the setting of BE. By bringing together research institutions with large populations of patients with BE, we will perform a multi-center study of FISH and hypermethylation markers as possible prognostic factors in BE. The centers will select from their cohorts who have progressed to HGD or to adenocarcinoma of the esophagus ("progressors"), and who also donated samples prior to the development of cancer, when their histology was felt to be benign. These subjects will be compared to individuals who have been under endoscopic surveillance, but who have not progressed to HGD or EAC ("non-progressors"). Using this approach, we hope to identify promising markers for risk stratification in BE. We expect to be able to make successful application for a prospective study of markers identified in this case-control study.

View Protocol
Decision rule: PMID:17452981
Barretts Esophagus Methylation Profiles
Study phase on the esophagus: 3

We propose a nested case-control study of biomarkers in the setting of BE. By bringing together research institutions with large populations of patients with BE, we will perform a multi-center study of FISH and hypermethylation markers as possible prognostic factors in BE. The centers will select from their cohorts who have progressed to HGD or to adenocarcinoma of the esophagus ("progressors"), and who also donated samples prior to the development of cancer, when their histology was felt to be benign. These subjects will be compared to individuals who have been under endoscopic surveillance, but who have not progressed to HGD or EAC ("non-progressors"). Using this approach, we hope to identify promising markers for risk stratification in BE. We expect to be able to make successful application for a prospective study of markers identified in this case-control study.

View Protocol
Decision rule: PMID:17452981
Esophagus-Specific Protocols
  • No organ-level protocols specified for esophagus.
Esophagus-Specific Publications
  • No organ-level publications were listed for esophagus.
Esophagus-Specific Resources
  • No organ-level resources were given for esophagus.