SMRP
Aliases:
This biomarker is also known as:- MSLN
- SMRP
- Soluble Mesothelin Related Peptide
Description…
Soluble mesothelin-related protein (SMRP) is related to the mesothelin family of molecules. It is overexpressed in ovarian cancer, malignant pleural mesothelioma (MPM), and certain other cancers. One hypothesis for the origin of SMRP is that this mesothelin-like molecule was released from tumor cells into culture supernatants, sera, and malignant effusions from certain tumors. Another hypothesis is that SMRP is actually a proteolytically cleaved fragment of membrane-bound mesothelin. Currently SMRP is considered to be an isoform of mesothelin (MSLN). UniprotKB/SwissProt lists isoform 3 of human mesothelin (identifier Q13421-2) as SMRP.
Datasets
There are no datasets associated with this biomarker.
Attributes
QA State: | Curated |
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Type: | Protein |
HGNC Name: | MSLN |
The following organs have data associated with this biomarker…
Attributes
Phase: | 4 |
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QA State: | Under Review |
Attributes
Phase: | 2 |
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QA State: | Under Review |
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access to this biomarker.
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- UniProtKB/Swiss-Prot entry for human mesothelin. SMRP is Isoform 3, identifier Q13421-2, in the Alternative products section.
- GeneCards entry for human mesothelin, MSLN, which lists SMRP as a synonym.
- HGNC entry for human mesothelin, MSLN
- Entrez Gene entry for human mesothelin, MSLN. Entrez Gene lists SMRP as a synonym for MSLN. SMRP is an alternative form of MSLN.