MMP7
Aliases:
This biomarker is also known as:- MMP-7
- Uterine metalloproteinase
- MPSL1
- matrix metalloproteinase 7 (matrilysin, uterine)
- MMP7
- PUMP-1
- Matrilysin
- Pump-1 protease
Description…
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.
Datasets
There are no datasets associated with this biomarker.
Attributes
| QA State: | Curated |
|---|---|
| Type: | Protein |
| HGNC Name: | MMP7 |
The following organs have data associated with this biomarker…
Attributes
| Phase: | 2 |
|---|---|
| QA State: |
Attributes
| Phase: | 3 |
|---|---|
| QA State: | Curated |
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access to this biomarker.
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