MGMT

Aliases:
This biomarker is also known as:
  • MGMT
  • methylguanine-DNA methyltransferase
  • methylated-DNA--protein-cysteine methyltransferase
  • O6-methylguanine-DNA methyltransferase
  • O-6-methylguanine-DNA methyltransferase
  • O-6-methylguanine-DNA-alkyltransferase
  • 6-O-methylguanine-DNA methyltransferase
  • EC 2.1.1.63

Description…

MGMT is involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. It repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Under Review
Type: Genomic
HGNC Name: MGMT

Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access to this biomarker.

Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access to this biomarker.

Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access to this biomarker.

Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access to this biomarker.

Version 5.1.0