PSA

Description…

KLK3, also known as PSA, or prostate specific antigen, a member of the kallikrein subgroup of serine proteases, is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Kallikreins are increasingly thought to be involved in carcinogenesis, and many act as cancer biomarkers. The product of the KLK3 gene is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum. KLK3, or PSA, is well known for its role in diagnosing and monitoring prostate cancer. There are several isoforms of KLK3, generated by alternate splicing and transcript variants.

The following organs have data associated with this biomarker…

Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access to this biomarker.

• Comparison Between Radiological Semantic Features and Lung-RADS in Predicting Malignancy of Screen-Detected Lung Nodules in the National Lung Screening Trial.
• Molecular markers of prostate cancer.
• Inactivation of TGF-β signaling and loss of PTEN cooperate to induce colon cancer in vivo.
• Initial analyses of colon cancer-specific antigen (CCSA)-3 and CCSA-4 as colorectal cancer-associated serum markers.
• Mining gene expression databases for association rules.

• NCBI Gene record for KLK3, also known as PSA, with links to protein isoforms of PSA
• HGNC entry for human KLK3
• OMIM entry for human KLK3
• UniProtKB/Swiss-Prot entry for human KLK3