• Glandular kallikrein-1
  • KLK2
  • KLK2A2
  • Kallikrein-2
  • MGC12201
  • Tissue kallikrein-2
  • glandular kallikrein 2
  • hGK-1
  • hK2
  • kallikrein 2, prostatic
  • kallikrein-related peptidase 2
The glandular kallikreins are a distinct group of serine proteases with molecular masses of 25,000 to 40,000. The glandular kallikrein gene family comprises 25 to 30 highly homologous genes that encode specific proteases involved in the processing of biologically active peptides (they cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin). Several human kallikrein genes have been isolated.
QA State
  • None
QA State for Prostate
Organ-Specific Notes

Human glandular kallikrein (hK2) has been shown to add important information regarding the early detection and staging of prostate cancer. Together with percent free PSA (%fPSA), hK2 may help to distinguish preoperatively between pT2 and pT3 prostate cancer.

Performance Comment

hK2, hK4 and hK11 do not distinguish cases from controls in these populations.

Supporting Study Data
Prostate Rapid Pre-Validation Set
Study phase on the prostate: 2

Determine which markers move to validation using the prospectie prostate reference set samples.

View Protocol
Decision rule: No clinically useful decision rule found.
Prostate Rapid Reference Set Application: Eleftherios Diamandis - Mt Sinai (2006)
Study phase on the prostate: 1

No description of this protocol is available.

View Protocol
Decision rule: No clinically useful decision rule found.
Prostate-Specific Protocols
  • No organ-level protocols specified for prostate.
Prostate-Specific Publications
  • No organ-level publications were listed for prostate.
Prostate-Specific Resources
  • No organ-level resources were given for prostate.
  • No science data collections were specified for this biomarker.