KLK2
Aliases:
This biomarker is also known as:- KLK2A2
- Tissue kallikrein-2
- hK2
- glandular kallikrein 2
- kallikrein-related peptidase 2
- kallikrein 2, prostatic
- MGC12201
- Glandular kallikrein-1
- hGK-1
- KLK2
- Kallikrein-2
Description…
The glandular kallikreins are a distinct group of serine proteases with molecular masses of 25,000 to 40,000. The glandular kallikrein gene family comprises 25 to 30 highly homologous genes that encode specific proteases involved in the processing of biologically active peptides (they cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin). Several human kallikrein genes have been isolated.
Datasets
There are no datasets associated with this biomarker.
Attributes
| QA State: | Accepted |
|---|---|
| Type: | Protein |
| HGNC Name: | KLK2 |
The following organs have data associated with this biomarker…
Attributes
| Phase: | 2 |
|---|---|
| QA State: | Accepted |
Overview
Human glandular kallikrein (hK2) has been shown to add important information regarding the early detection and staging of prostate cancer. Together with percent free PSA (%fPSA), hK2 may help to distinguish preoperatively between pT2 and pT3 prostate cancer.
Performance Comment
hK2, hK4 and hK11 do not distinguish cases from controls in these populations.
Supporting Study Data
The following studies/protocols provide evidence supporting KLK2 indications for the Prostate…
Prostate Rapid Pre-Validation Set
Determine which markers move to validation using the prospectie prostate reference set samples.
View more about this studyBiomarker Characteristics Summary
No statistics found.
Decision Rule
No clinically useful decision rule found.
Additional Study-Specific Protocols
Study-Specific Publications
No study-specific publications defined.
Study-Specific Resources
No study-specific resources defined.
Prostate Rapid Reference Set Application: Eleftherios Diamandis - Mt Sinai (2006)
A blinded study coordinated by the EDRN GU Collaborative Group found the biomarker is not associated with prostate cancer risk
View more about this studyBiomarker Characteristics Summary
No statistics found.
Decision Rule
No clinically useful decision rule found.
Additional Study-Specific Protocols
Study-Specific Publications
No study-specific publications defined.
Study-Specific Resources
No study-specific resources defined.
Organ-Specific Protocols
No organ-specific protocols defined.
Organ-Specific Publications
No organ-specific publications defined.
Organ-Specific Resources
No organ-specific resources defined.