Aliases

• EC 2.5.1.18
• GST class-theta-1
• GSTT1
• Glutathione transferase T1-1
• glutathione S-transferase theta 1
• glutathione S-transferase theta-1
• glutathione transferase T1-1

Description

The GSTT1 gene encodes glutathione S-transferase theta 1, a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. This group of proteins can be subdivided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1 and GSTT2. The GSTT1 and GSTT2 share 55% amino acid sequence identity and both of them were claimed to have an important role in human carcinogenesis. The GSTT1 gene is located approximately 50kb away from the GSTT2 gene. The GSTT1 and GSTT2 genes have a similar structure, being composed of five exons with identical exon/intron boundaries. GSTT1 is found in erythrocytes and is expressed at low levels in liver. In lung, it is expressed at low levels in Clara cells and ciliated cells at the alveolar/bronchiolar junction. It is absent from epithelial cells of larger bronchioles.

Attributes

QA State

Under Review

Type

Gene

HGNC Name

GSTT1