FOLH1

Aliases:
This biomarker is also known as:
  • Folate hydrolase 1
  • folylpoly-gamma-glutamate carboxypeptidase
  • glutamate carboxypeptidase II
  • Folylpoly-gamma-glutamate carboxypeptidase
  • mGCP
  • membrane glutamate carboxypeptidase
  • Cell growth-inhibiting gene 27 protein
  • NAALAdase
  • folate hydrolase (prostate-specific membrane antigen) 1
  • GCPII
  • FGCP
  • Prostate-specific membrane antigen
  • glutamate carboxylase II
  • PSMA
  • NAALAD1
  • FOLH
  • prostate specific membrane antigen variant F
  • EC 3.4.17.21
  • Membrane glutamate carboxypeptidase
  • Pteroylpoly-gamma-glutamate carboxypeptidase
  • cell growth-inhibiting gene 27 protein
  • N-acetylated alpha-linked acidic dipeptidase 1
  • pteroylpoly-gamma-glutamate carboxypeptidase
  • GCP2
  • Glutamate carboxypeptidase II
  • NAALADase I
  • N-acetylated-alpha-linked acidic dipeptidase I
  • FOLH1
  • PSM
  • glutamate carboxypeptidase 2

Description…

From NCBI Gene: This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms. [provided by RefSeq, Jul 2010]

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Under Review
Type: Gene
HGNC Name: FOLH1

Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access to this biomarker.

Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access to this biomarker.

Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access to this biomarker.

Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access to this biomarker.

Version 5.1.0