FHIT

Aliases:
This biomarker is also known as:
  • Dinucleosidetriphosphatase
  • tumor suppressor protein
  • FHIT
  • dinucleosidetriphosphatase
  • AP3Aase
  • AP3A hydrolase
  • EC 3.6.1.29
  • fragile histidine triad gene
  • FRA3B
  • Fragile histidine triad protein
  • bis(5'-adenosyl)-triphosphatase
  • Diadenosine 5',5'''-P1,P3-triphosphate hydrolase
  • diadenosine 5',5'''-P1,P3-triphosphate hydrolase

Description…

FHIT, or fragile histidine triad, is a member of the histidine triad gene family. The FHIT protein is a diadenosine 5',5'''-P1,P3-triphosphate hydrolase involved in purine metabolism. Included in the FHIT gene is the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. Mutated transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. There are several alternatively spliced transcript variants for this gene.

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Under Review
Type: Protein
HGNC Name: FHIT

Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access to this biomarker.

Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access to this biomarker.

Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access to this biomarker.

Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access to this biomarker.

Version 5.1.0