ERCC5

Aliases
  • COFS3
  • DNA excision repair protein ERCC-5
  • DNA repair protein complementing XP-G cells
  • EC 3.1.-.-
  • ERCC5
  • ERCM2
  • UVDR
  • XPG
  • XPG-complementing protein
  • XPGC
  • Xeroderma pigmentosum group G-complementing protein
  • excision repair cross-complementing rodent repair deficiency, complementation group 5
  • xeroderma pigmentosum, complementation group G
Description
The ERCC5 gene encodes a single-stranded structure-specific DNA endonuclease involved in DNA excision repair following UV-induced damage. ERCC5 makes the 3'incision in DNA nucleotide excision repair (NER) and acts as a cofactor for a DNA glycosylase that removes oxidized pyrimidines from DNA. The ERCC5 protein may also function in other cellular processes, including RNA polymerase II transcription, and transcription-coupled DNA repair. Mutations in this gene cause xeroderma pigmentosum complementation group G (XP-G), which is also referred to as xeroderma pigmentosum VII (XP7), a skin disorder characterized by hypersensitivity to UV light and increased susceptibility for skin cancer development following UV exposure. Read-through transcription exists between this gene and the neighboring upstream BIVM (basic, immunoglobulin-like variable motif containing) gene.
Attributes
QA State
Under Review
Type
Gene
HGNC Name
ERCC5
Certifications
  • None
QA State for Lung
Under Review

 Non-Public Biomarker

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 Non-Public Biomarker

Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.

 Non-Public Biomarker

Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.

 Non-Public Biomarker

Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.

 Non-Public Biomarker

Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.