EPCAM

Aliases:
This biomarker is also known as:
  • TACSTD1
  • Ep-CAM
  • 17-1A
  • MOC31
  • HEA125
  • TROP1
  • M4S1
  • CO-17A
  • EGP34
  • CD326
  • HNPCC8
  • EPCAM
  • KS1/4
  • epithelial cell adhesion molecule
  • EGP-2
  • EGP314
  • Ly74
  • tumor-associated calcium signal transducer 1
  • TACST-1
  • EGP40
  • MIC18
  • 323/A3
  • GA733-2
  • MK-1
  • KSA
  • ESA
  • antigen identified by monoclonal antibody AUA1
  • DIAR5
  • MH99

Description…

This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. The EPCAM antigen, a single-pass type 1 membrane protein, is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. EPCAM may act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. It plays a role in embryonic stem cells proliferation and differentiation. EPCAM p-regulates the expression of FABP5, MYC and cyclins A and E. EPCAM is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy.

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Under Review
Type: Protein
HGNC Name: EPCAM

Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access to this biomarker.

Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access to this biomarker.

Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access to this biomarker.

Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access to this biomarker.

Version 5.1.0