Aliases

• DENN domain-containing protein 2B
• DENN/MADD domain containing 2B
• DENND2B
• HTS1
• HeLa tumor suppression 1
• ST5
• heLa tumor suppression 1
• p126
• suppression of tumorigenicity 5
• suppression of tumorigenicity 5 protein

Description

From NCBI Gene: This gene was identified by its ability to suppress the tumorigenicity of Hela cells in nude mice. The protein encoded by this gene contains a C-terminal region that shares similarity with the Rab 3 family of small GTP binding proteins. This protein preferentially binds to the SH3 domain of c-Abl kinase, and acts as a regulator of MAPK1/ERK2 kinase, which may contribute to its ability to reduce the tumorigenic phenotype in cells. Three alternatively spliced transcript variants of this gene encoding distinct isoforms are identified. [provided by RefSeq, Jul 2008]

Attributes

QA State

Under Review

Type

Gene

HGNC Name

DENND2B