Aliases

• CST6
• Cystatin M/E
• Cystatin-6
• Cystatin-E
• Cystatin-M
• Cysteine Proteinase Inhibitor
• cystatin E/M

Description

CST6, a type 2 cystatin protein, is down-regulated in metastatic breast tumor cells as compared to primary tumor cells. Loss of expression is likely associated with the progression of a primary tumor to a metastatic phenotype. The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins, which includes CST6, are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions.

Attributes

QA State

Under Review

Type

Protein

HGNC Name

CST6