Aliases

• C-C motif chemokine 5
• CCL5
• D17S136E
• EoCP
• Eosinophil chemotactic cytokine
• MGC17164
• RANTES
• SCYA5
• SIS-delta
• SISd
• Small-inducible cytokine A5
• T cell-specific protein P228
• T-cell specific protein p288
• T-cell-specific protein RANTES
• TCP228
• beta-chemokine RANTES
• chemokine (C-C motif) ligand 5
• eoCP
• eosinophil chemotactic cytokine
• regulated upon activation, normally T-expressed, and presumably secreted
• small inducible cytokine A5 (RANTES)
• small inducible cytokine subfamily A (Cys-Cys), member 5
• small-inducible cytokine A5
• t cell-specific protein P228

Description

From NCBI Gene: This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]

Attributes

QA State

Curated

Type

Protein

HGNC Name

CCL5