BRCA1

Aliases
  • BRCA1
  • BRCA1/BRCA2-containing complex, subunit 1
  • BRCAI
  • BRCC1
  • BROVCA1
  • EC 6.3.2.-
  • IRIS
  • PNCA4
  • PPP1R53
  • PSCP
  • RING finger protein 53
  • RNF53
  • breast and ovarian cancer susceptibility protein 1
  • breast and ovarian cancer sususceptibility protein 1
  • breast cancer 1, early onset
  • breast cancer type 1 susceptibility protein
  • protein phosphatase 1, regulatory subunit 53
Description
BRCA1 is a nuclear phosphoprotein that functions as a tumor suppressor. BRCA1 combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). BRCA1 associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers.
Attributes
QA State
Curated
Type
Protein
HGNC Name
BRCA1
Certifications
  • None
QA State for Breast
Under Review

 Non-Public Biomarker

Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.

Certifications
  • None
QA State for Ovary
Under Review

 Non-Public Biomarker

Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.

 Non-Public Biomarker

Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.

 Non-Public Biomarker

Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.