BRCA1

Aliases:
This biomarker is also known as:
  • breast and ovarian cancer sususceptibility protein 1
  • IRIS
  • PPP1R53
  • BROVCA1
  • breast cancer type 1 susceptibility protein
  • BRCC1
  • PNCA4
  • RING finger protein 53
  • protein phosphatase 1, regulatory subunit 53
  • PSCP
  • breast and ovarian cancer susceptibility protein 1
  • RNF53
  • BRCAI
  • EC 6.3.2.-
  • breast cancer 1, early onset
  • BRCA1
  • BRCA1/BRCA2-containing complex, subunit 1

Description…

BRCA1 is a nuclear phosphoprotein that functions as a tumor suppressor. BRCA1 combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). BRCA1 associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers.

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Curated
Type: Protein
HGNC Name: BRCA1

The following organs have data associated with this biomarker…

Attributes

Phase: 2
QA State: Under Review
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access to this biomarker.

Attributes

Phase: 2
QA State: Under Review
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access to this biomarker.

Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access to this biomarker.

Version 5.1.0