Aliases

• Apoptosis regulator Bcl-W
• BCL-W
• BCL2-L-2
• BCL2-like 2
• BCL2L2
• BCLW
• Bcl2-L-2
• KIAA0271
• PPP1R51
• apoptosis regulator BCL-W
• bcl-2-like protein 2
• protein phosphatase 1
• protein phosphatase 1, regulatory subunit 51
• regulatory subunit 51

Description

From NCBI Gene: This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene. [provided by RefSeq, Dec 2010]

Attributes

QA State

Under Review

Type

Protein

HGNC Name

BCL2L2