Aliases

• ATP6G
• ATP6G1
• ATP6GL
• ATP6J
• ATP6V1G1
• ATPase, H+ transporting, lysosomal (vacuolar proton pump), member J
• ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G isoform 1
• ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1
• DKFZp547P234
• V-ATPase 13 kDa subunit 1
• V-ATPase subunit G 1
• V-type proton ATPase subunit G 1
• Vacuolar proton pump subunit G 1
• Vacuolar proton pump subunit M16
• Vma10
• vacuolar ATP synthase subunit M16
• vacuolar H(+)-ATPase subunit G 1
• vacuolar proton pump subunit G 1
• vacuolar proton pump subunit M16

Description

ATP6V1G1 is a subunit of vacuolar ATPase (V-ATPase), a multisubunit enzyme. V-ATPase is an enzyme transporter that functions to acidify intracellular compartments in eukaryotic cells. This acidification process is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is ubiquitously expressed and is present in endomembrane organelles such as vacuoles, lysosomes, endosomes, the Golgi apparatus, chromaffin granules and coated vesicles, as well as in the plasma membrane. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site.

Attributes

QA State

Curated

Type

Protein

HGNC Name

ATP6V1G1