APEX1
- Aliases
-
- AP Endonuclease 1
- AP Endonuclease Class I
- AP Lyase
- APE
- APE-1
- APE1
- APEN
- APEX
- APEX Nuclease
- APEX Nuclease (Multifunctional DNA Repair Enzyme)
- APEX Nuclease (Multifunctional DNA Repair Enzyme) 1
- APEX1
- APX
- Apurinic-Apyrimidinic Endonuclease 1
- Apurinic/Apyrimidinic (Abasic) Endonuclease
- DNA-(Apurinic Or Apyrimidinic Site) Lyase
- Deoxyribonuclease (Apurinic Or Apyrimidinic)
- EC 4.2.99.18
- HAP1
- Protein REF-1
- REF-1
- REF1
- Redox Factor-1
- Description
- APEX1 is the major endonuclease in human cells, playing a role in DNA repair and the celluar response to oxidative stress. APEX1 is an apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Several splice variants have been identified for this gene, all encoding the same protein.
Attributes
- QA State
- Under Review
- Type
- Protein
- HGNC Name
- APEX1
- Certifications
-
- None
- QA State for Lung
- Under Review
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.