APEX1

Aliases:
This biomarker is also known as:
  • APE
  • HAP1
  • APEX
  • EC 4.2.99.18
  • APEX Nuclease
  • APE-1
  • Apurinic/Apyrimidinic (Abasic) Endonuclease
  • Apurinic-Apyrimidinic Endonuclease 1
  • AP Endonuclease 1
  • AP Endonuclease Class I
  • DNA-(Apurinic Or Apyrimidinic Site) Lyase
  • APX
  • APEX1
  • Deoxyribonuclease (Apurinic Or Apyrimidinic)
  • Protein REF-1
  • REF-1
  • AP Lyase
  • APEX Nuclease (Multifunctional DNA Repair Enzyme) 1
  • Redox Factor-1
  • APEX Nuclease (Multifunctional DNA Repair Enzyme)
  • REF1
  • APEN
  • APE1

Description…

APEX1 is the major endonuclease in human cells, playing a role in DNA repair and the celluar response to oxidative stress. APEX1 is an apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Several splice variants have been identified for this gene, all encoding the same protein.

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Under Review
Type: Protein
HGNC Name: APEX1

Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access to this biomarker.

Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access to this biomarker.

Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access to this biomarker.

Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access to this biomarker.

Version 5.1.0